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If indicated, other possible risk factors for hepatotoxicity should be identified. Despite the advances made over the years, there is a continued need to develop new diagnostic tools and therapies to combat this complex disease. Each year, there are nearly 500,000 hospitalizations and close to two million visits to the Emergency Department. Nearly one quarter of adults with asthma missed work during the prior year due to asthma and over one third of parents of asthmatics missed work in the prior year. The annual direct and indirect health cost is estimated at over 16 billion dollars. Fortunately the overall mortality of asthma in the United States appears to be decreasing.

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